BDBM575656 US11459340, Compound 38::of (3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)-6-((2-chloro-8- methoxy-6,7,8,9-tetrahydro-5H-pyrido[3,2-b] indol-3-yl)thio)pyrazin-2-yl)-methanol

SMILES COC1CCc2[nH]c3cc(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)c(Cl)nc3c2C1

InChI Key InChIKey=FRCMFUVQLFCGGF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575656   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575656(US11459340, Compound 38 | of (3-((3S,4S)-4-amino-3...)
Affinity DataIC50: 5.5nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent