BDBM575654 13-amino-10-(5-((2-amino-3-chloropyridin- 4-yl)thio)-3-(hydroxymethyl)-pyrazin-2- yl)-1-methyl-1,10- diazadispiro[4.1.57.25]tetradecan-2-one::US11459340, Compound 36

SMILES CN1C(=O)CCC11CC(N)C2(C1)CCN(CC2)c1ncc(Sc2ccnc(N)c2Cl)nc1CO

InChI Key InChIKey=QZDQSPXNIZADJU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575654   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575654(US11459340, Compound 36 | 13-amino-10-(5-((2-amino...)
Affinity DataIC50: 269nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent