BDBM575628 (3S,4S)-8-(5-((3-chloro-2-methoxypyridin- 4-yl)thio)-3-(methylsulfinyl)pyrazin- 2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan- 4-amine::US11459340, Compound 7

SMILES COc1nccc(Sc2cnc(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)c(n2)S(C)=O)c1Cl

InChI Key InChIKey=KMIPGWLKADTXHS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575628   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575628(US11459340, Compound 7 | (3S,4S)-8-(5-((3-chloro-2...)
Affinity DataIC50: 18nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent