BDBM575625 (3S,4S)-8-(5-((2-amino-3-chloropyridin-4- yl)thio)-3-(methylsulfinyl) pyrazin-2-yl)-3-methyl-2-oxa-8- azaspiro[4.5]decan-4-amine::US11459340, Compound 4

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc(N)c3Cl)nc2S(C)=O)[C@@H]1N

InChI Key InChIKey=JSJKLATYRIFSDG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575625   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575625(US11459340, Compound 4 | (3S,4S)-8-(5-((2-amino-3-...)
Affinity DataIC50: 13nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent