BDBM575201 US11459333, Compound 133

SMILES CCOC(=O)[C@@H]1C[C@H](CN1C)OC(=O)Cn1cc(Nc2ncc3ccn(C[C@@H](CC)C(C)C)c3n2)cn1

InChI Key InChIKey=DPZDIVFZWBVSFK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 575201   

TargetTyrosine-protein kinase JAK1(Human)
Vimalan Biosciences

US Patent
LigandPNGBDBM575201(US11459333, Compound 133)
Affinity DataIC50: 100nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Vimalan Biosciences

US Patent
LigandPNGBDBM575201(US11459333, Compound 133)
Affinity DataIC50: 100nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Vimalan Biosciences

US Patent
LigandPNGBDBM575201(US11459333, Compound 133)
Affinity DataIC50: 100nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Vimalan Biosciences

US Patent
LigandPNGBDBM575201(US11459333, Compound 133)
Affinity DataIC50: 100nMAssay Description:10 mM test compound stock or 1 mM control compound stock (tofocitinib, ruxolitinib or staurosporine) in DMSO was diluted to 0.4 mM in DMSO. A 3-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent