BDBM573838 (5R,7R,8R,12aR,14R,15R,15aR,16R)-7-(2- amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6- amino-9H-purin-9-yl)-15-fluoro-16- hydroxyoctahydro-12H-5,8-methanofuro[3,2-l] [1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine- 2,10-diolate 2,10-dioxide::US11453697, Example 2::US11453697, Example 7

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)OC3[C@@H](COP(O)(=O)O[C@H]1C2O)O[C@H]([C@H]3F)n1cnc2c(N)ncnc12

InChI Key InChIKey=VSWSFOHKUMIXAS-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 573838   

LigandPNGBDBM573838(US11453697, Example 2 | US11453697, Example 7 | (5...)
Affinity DataEC50:  1.30nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573838(US11453697, Example 2 | US11453697, Example 7 | (5...)
Affinity DataEC50:  1.20nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573838(US11453697, Example 2 | US11453697, Example 7 | (5...)
Affinity DataEC50:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573838(US11453697, Example 2 | US11453697, Example 7 | (5...)
Affinity DataEC50: <1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent