BDBM573154 US11453673, Example 15

SMILES Cc1c(C)n2c(nnc2c(=O)n1CC1(C)CC1)C1(CC1)C1CC1

InChI Key InChIKey=LEQGDWSFJKSNPY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 573154   

LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50: 3.10nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50: 4.90nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50: 1.40nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50: 9.60E+3nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
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Date in BDB:
12/4/2022
Entry Details
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50: 1.40E+4nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573154(US11453673, Example 15)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent