BDBM573145 US11453673, Example 7

SMILES CCC1(CC1)c1nnc2n1c(C)c(C)n(CC1CCCCO1)c2=O

InChI Key InChIKey=UFODZZUTBCVMAU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 573145   

LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50: 32.7nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
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Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50: 28.5nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50: 7.76nMAssay Description:TABLE 5: All 3′, 5′ cyclic nucleotide PDE enzyme activities are measured with a radiometric enzyme assay based on SPA detection system. C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50: 1.00E+5nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
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Date in BDB:
12/4/2022
Entry Details
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50: 4.65E+4nMAssay Description:Table 6: The following PDE activities are measured using [3H]cAMP as reaction substrate: human PDE3A (catalytic domain) and human PDE4D. Both enzymes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573145(US11453673, Example 7)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 7: The following phosphodiesterase activities are measured using [3H]cGMP as reaction substrate: human PDE6A/6B. The catalytic active form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent