BDBM572255 3-methyl-1-(3-thiazol-2-yl-1H-pyrrolo[2,3-b]pyridin-4- yl)piperidin-3-amine::US11447505, Example E176

SMILES CC1(N)CCCN(C1)c1ccnc2[nH]cc(-c3ncc[nH]3)c12

InChI Key InChIKey=WVKCMVMISLIFTD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572255   

TargetSerine/threonine-protein kinase MRCK beta(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572255(3-methyl-1-(3-thiazol-2-yl-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataKi:  0.0920nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase MRCK alpha(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572255(3-methyl-1-(3-thiazol-2-yl-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataKi:  0.0930nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572255(3-methyl-1-(3-thiazol-2-yl-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataKi:  42nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572255(3-methyl-1-(3-thiazol-2-yl-1H-pyrrolo[2,3-b]pyridi...)
Affinity DataKi:  67.1nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent