BDBM572199 (+)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 1::US11447504, Example 52

SMILES CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C

InChI Key InChIKey=SSTSSUXFOIWKBG-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 572199   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide(Human)
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US Patent

LigandBDBM572199((+)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-...)Copy SMILESCopy InChI

Affinity DataIC50: 0.870nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/20/2022
Entry Details
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