BDBM572009 Preparation of 2-(((αR)-6-((3R)-2,5-dioxo-3-(3,3,3-trifluoro-2-methylpropyl)pyrrolidin-1-yl)spiro[3.3]heptan-2-yl)oxy)-6-methoxynicotinamide::US11447487, Example 102

SMILES COc1ccc(C(N)=O)c(O[C@H]2C[C@]3(C2)C[C@@H](C3)N2C(=O)N[C@@H](CC(C)C(F)(F)F)C2=O)n1

InChI Key InChIKey=GVCFSRASUXDDTR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 572009   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM572009(Preparation of 2-(((αR)-6-((3R)-2,5-dioxo-3-(...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
US Patent