BDBM572000 2-(((alphaR)-6-((S)-2,5- dioxo-4-((S)-3,3,3- trifluoro-2- methylpropyl) imidazolidin-1- yl)spiro[3.3]heptan- 2- yl)oxy)nicotinamide::US11447487, Example 93

SMILES C[C@@H](C[C@@H]1NC(=O)N([C@H]2C[C@@]3(C[C@@H](C3)Oc3ncccc3C(N)=O)C2)C1=O)C(F)(F)F

InChI Key InChIKey=QBNUHJBMHSMJNH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 572000   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM572000(2-(((alphaR)-6-((S)-2,5- dioxo-4-((S)-3,3,3- trifl...)
Affinity DataIC50: 9nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent