BDBM571994 2-(((alphaR)-6-(2.5- dioxo-3-(4- (trifluoromethyl) phenyl)imidazolidin-1- yl)spiro[3.3]heptan- 2- yl)oxy)nicotinamide::US11447487, Example 87

SMILES NC(=O)c1cccnc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)CN(C1=O)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=JJHFHORBCIKWGL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 571994   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571994(2-(((alphaR)-6-(2.5- dioxo-3-(4- (trifluoromethyl)...)
Affinity DataIC50: 5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent