BDBM571990 2-(((alphaR)-6-(2,5- dioxo-3-(4- phenoxyphenyl) imidazolidin-1- yl)spiro[3.3]heptan- 2- yl)oxy)nicotinamide::US11447487, Example 83

SMILES NC(=O)c1cccnc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)CN(C1=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=IGUZBMGPGIICFE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 571990   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571990(2-(((alphaR)-6-(2,5- dioxo-3-(4- phenoxyphenyl) im...)
Affinity DataIC50: 9nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
US Patent