BDBM571954 2-{[(alphaR)-6-{4- [(3,3,3,3',3',3'- hexafluoroiso- butyl]-2,5-dioxo- imidazolidin-1-yl}- spiro[3.3]heptan- 2-yl]oxy}pyridine- 3-carboxamide::US11447487, Example 47

SMILES NC(=O)c1cccnc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)NC(CC(C(F)(F)F)C(F)(F)F)C1=O

InChI Key InChIKey=ZPLMPFXBCRUHQP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 571954   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571954(2-{[(alphaR)-6-{4- [(3,3,3,3',3',3'- hexafluoroiso...)
Affinity DataIC50: 50nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
US Patent