BDBM571949 2-{[(alphaR)-6-[2,5- dioxo-4-(4,4,4- trifluorobutyl)- imidazolidin-1-yl]- spiro[3.3]heptan- 2-yl]oxy}pyridine- 3-carboxamide::US11447487, Example 42::US11447487, Example 60

SMILES NC(=O)c1cccnc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)NC(CCCC(F)(F)F)C1=O

InChI Key InChIKey=YNLHATFZTJHOOW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571949   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571949(2-{[(alphaR)-6-[2,5- dioxo-4-(4,4,4- trifluorobuty...)
Affinity DataIC50: 22nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571949(2-{[(alphaR)-6-[2,5- dioxo-4-(4,4,4- trifluorobuty...)
Affinity DataIC50: 311nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent