BDBM571909 2-{[(alphaR)-6-[4- (cyclohexyl- methyl)-2,5- dioxoimidazol- idin-1-yl]spiro- [3.3]heptan-2-yl]- oxy}pyridine-3- carboxamide::US11447487, Example 2::US11447487, Example 6

SMILES NC(=O)c1cccnc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)NC(CC2CCCCC2)C1=O

InChI Key InChIKey=SEOZAZLJUKZPAP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571909   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571909(US11447487, Example 6 | 2-{[(alphaR)-6-[4- (cycloh...)
Affinity DataIC50: 8nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571909(US11447487, Example 6 | 2-{[(alphaR)-6-[4- (cycloh...)
Affinity DataIC50: 91nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent