BDBM571517 4-chloro-15-[2-(dimethylamino)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Stereoisomer 1)::US11440923, Example 82::US11440923, Example 83::US11440923, Example 84::US11440923, Example 85

SMILES CCc1c-2c(nn1C)C(CCN(C)C)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13

InChI Key InChIKey=IDDPEDPZMHSKMH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 571517   

LigandPNGBDBM571517(US11440923, Example 84 | US11440923, Example 85 | ...)
Affinity DataIC50: 42nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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LigandPNGBDBM571517(US11440923, Example 84 | US11440923, Example 85 | ...)
Affinity DataIC50: 1.10nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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LigandPNGBDBM571517(US11440923, Example 84 | US11440923, Example 85 | ...)
Affinity DataIC50: 16nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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LigandPNGBDBM571517(US11440923, Example 84 | US11440923, Example 85 | ...)
Affinity DataIC50: 3.90nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent