BDBM5715 (+/-)-(3SR,4RS)-2-[(4,6-Dimethylpyrimidin-2-yl)thio]-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-4H-1-benzopyran-4-one::2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one::CHEMBL323015::Flavopiridol analogue 24

SMILES CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(Sc1nc(C)cc(C)n1)cc2=O

InChI Key InChIKey=SVSLKZGKLLNZJL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5715   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5715(2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-5,7-dihyd...)
Affinity DataIC50: 6.40E+3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5715(2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-5,7-dihyd...)
Affinity DataIC50: 4.04E+4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5715(2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-5,7-dihyd...)
Affinity DataIC50: 8.25E+4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM5715(2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-5,7-dihyd...)
Affinity DataIC50: 4.04E+4nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed