BDBM571433 (3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2- yn-1-ylidene]-3,3- difluoropiperidin-1- yl}methanone::US11440922, Example 201

SMILES FC1(F)CN(CC\C1=C/C#Cc1cccc(Cl)c1)C(=O)c1cccc(Cl)c1

InChI Key InChIKey=YQMKYHUTXUVXOE-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571433   

TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571433((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataEC50:  88.2nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571433((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataKi:  1.91nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent