BDBM571430 US11440922, Example 167::{(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-3,3- dimethylpiperidin-1-yl}(2- ethyl-5-methyl-2H-1,2,3- triazol-4-yl)methanone

SMILES CCn1nc(C)c(n1)C(=O)N1CC\C(=C/C#Cc2cccc(Cl)c2)C(C)(C)C1

InChI Key InChIKey=KFATUMYNBDXCDZ-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571430   

TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571430({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  23nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571430({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataKi:  2.42nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent