BDBM571421 US11440922, Example 91::ethyl (3E)-3-[3-(4- chloropyridin-2-yl)prop-2- yn-1-ylidene]-2,2- dimethylpyrrolidine-1- carboxylate

SMILES CCOC(=O)N1CC\C(=C/C#Cc2cc(Cl)ccn2)C1(C)C

InChI Key InChIKey=IQJAGKSXVXYRIE-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571421   

TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571421(ethyl (3E)-3-[3-(4- chloropyridin-2-yl)prop-2- yn-...)
Affinity DataIC50: 31.6nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571421(ethyl (3E)-3-[3-(4- chloropyridin-2-yl)prop-2- yn-...)
Affinity DataKi:  16.3nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent