BDBM571413 US11440922, Example 32::ethyl (4E)-4-[3-(3-cyano-5- fluorophenyl)prop-2-yn-1- ylidene]-3,3- dimethylpiperidine-1- carboxylate

SMILES CCOC(=O)N1CC\C(=C/C#Cc2cc(F)cc(c2)C#N)C(C)(C)C1

InChI Key InChIKey=ZHJGOGUQHDIXEV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571413   

TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571413(ethyl (4E)-4-[3-(3-cyano-5- fluorophenyl)prop-2-yn...)
Affinity DataIC50: 60nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
Recordati Industria Chimica E Farmacentica

US Patent
LigandPNGBDBM571413(ethyl (4E)-4-[3-(3-cyano-5- fluorophenyl)prop-2-yn...)
Affinity DataKi:  16.1nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent