BDBM571402 (9R)-9-(2-fluorophenyl)-N-[4-(4-methylimidazol-1-yl)-1-bicyclo[2.2.2]octanyl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-2-amine and (9S)-9-(2-fluorophenyl)-N-[4-(4-methylimidazol-1-yl)-1-bicyclo[2.2.2]octanyl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-2-amine::US11440915, Example 17

SMILES Cc1cn(cn1)C12CCC(CC1)(CC2)Nc1nc2[C@H](CCCCn2n1)c1ccccc1F

InChI Key InChIKey=CEKXSDAIYFHPDO-UHFFFAOYSA-N

Data  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 571402   

TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Human)
Hoffmann-La Roche

US Patent

LigandBDBM571402(US11440915, Example 17 | (9R)-9-(2-fluorophenyl)-N...)Copy SMILESCopy InChI

Affinity DataEC50:  56nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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