BDBM571345 3-{2- acetamidoimidazo [1,2-b]pyridazin- 6-yl}-2-fluoro- N-{[2-fluoro-5- (trifluoromethoxy) phenyl]methyl} benzamide::US11440913, Example 424::US11440913, Example 426

SMILES CC(=O)Nc1cn2nc(ccc2n1)-c1cccc(C(=O)NCc2cc(OC(F)(F)F)ccc2F)c1F

InChI Key InChIKey=AAKFJZRYRJEPGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571345   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571345(3-{2- acetamidoimidazo [1,2-b]pyridazin- 6-yl}-2-f...)
Affinity DataIC50: 1nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571345(3-{2- acetamidoimidazo [1,2-b]pyridazin- 6-yl}-2-f...)
Affinity DataIC50: 2nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent