BDBM571108 5-{2-acetamidoimidazo[1,2-b] pyridazin-6-yl}-N-{[2-fluoro-5- (trifluoromethoxy)phenyl](deutero) methyl}-2-(deutero)methoxy-6- methylpyridine-3-carboxamide::BDBM571112::US11440913, Example 175

SMILES COc1nc(C)c(cc1C(=O)NCc1cc(OC(F)(F)F)ccc1F)-c1ccc2nc(NC(C)=O)cn2n1

InChI Key InChIKey=QNNGKHDFSWSUBF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 571108   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571108(BDBM571112 | 5-{2-acetamidoimidazo[1,2-b] pyridazi...)
Affinity DataIC50: 3nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571108(BDBM571112 | 5-{2-acetamidoimidazo[1,2-b] pyridazi...)
Affinity DataIC50: 4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571108(BDBM571112 | 5-{2-acetamidoimidazo[1,2-b] pyridazi...)
Affinity DataIC50: 6nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571108(BDBM571112 | 5-{2-acetamidoimidazo[1,2-b] pyridazi...)
Affinity DataIC50: 10nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent