BDBM570978 N-{[3,5-difluoro-2-(oxan-3- yloxy)phenyl]methyl}-5-{2- acetamidoimidazo[1,2-b]pyridazin- 6-yl}-2-(D3)methoxypyridine- 3-carboxamide::US11440913, Example 43::US11440913, Example 46::US11440913, Example 99

SMILES COc1ncc(cc1C(=O)NCc1cc(F)cc(F)c1OC1CCCOC1)-c1ccc2nc(NC(C)=O)cn2n1

InChI Key InChIKey=OUXSHWXSJCGFGD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 570978   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM570978(US11440913, Example 99 | US11440913, Example 46 | ...)
Affinity DataIC50: 2nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM570978(US11440913, Example 99 | US11440913, Example 46 | ...)
Affinity DataIC50: 6nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM570978(US11440913, Example 99 | US11440913, Example 46 | ...)
Affinity DataIC50: 10nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPK1(1-324) in FRET Buffer (20 mM HEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent