BDBM570928 US11440904, Compound 28

SMILES CC(=O)Nc1cc(F)ccc1Nc1nc(Nc2ccc3OCCOCCOCCOc3c2)nc2[nH]cnc12

InChI Key InChIKey=GFEWEPZLEYQMJH-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 570928   

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 9.37nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 9.37nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 9.37nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 31.5nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 31.5nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 31.5nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 83.4nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 83.4nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570928(US11440904, Compound 28)
Affinity DataIC50: 83.4nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent