BDBM570906 US11440904, Compound 4

SMILES CCC(=O)N1CCC[C@H](C1)Nc1nc(Nc2ccc3OCCOCCOCCOc3c2)nc2[nH]cnc12

InChI Key InChIKey=LVQAGIXEFVAFEO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 570906   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 19.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 19.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 144nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 144nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 1.15E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 1.45E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Milstein Zhang & Wu

US Patent
LigandPNGBDBM570906(US11440904, Compound 4)
Affinity DataIC50: 1.45E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent