BDBM568359 US11420975, Compound A-10-12::US12291534, Compound A-10-12

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)C12CCC(CC1)(C2)NC(=O)C1(CC1)C#N

InChI Key InChIKey=XVHSVVGAMXHAOL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 568359   

TargetTyrosine-protein kinase BTK(Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568359(US11420975, Compound A-10-12 | US12291534, Compoun...)
Affinity DataIC50: 5.5nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, Mo.) to the substrate reaction buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568359(US11420975, Compound A-10-12 | US12291534, Compoun...)
Affinity DataIC50: 0.550nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, Mo.) to the substrate reaction buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568359(US11420975, Compound A-10-12 | US12291534, Compoun...)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568359(US11420975, Compound A-10-12 | US12291534, Compoun...)
Affinity DataIC50: 0.550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent