BDBM568347 US11420975, Compound A-7-5::US12291534, Compound A-7-5

SMILES CC#CC(=O)NC12CCC(CC1)(C2)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C#N)c2c(N)nccn12

InChI Key InChIKey=NKZUQAYGQWGRPV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 568347   

TargetTyrosine-protein kinase BTK(Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568347(US11420975, Compound A-7-5 | US12291534, Compound ...)
Affinity DataIC50: 5.5nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, Mo.) to the substrate reaction buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568347(US11420975, Compound A-7-5 | US12291534, Compound ...)
Affinity DataIC50: 0.550nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, Mo.) to the substrate reaction buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568347(US11420975, Compound A-7-5 | US12291534, Compound ...)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568347(US11420975, Compound A-7-5 | US12291534, Compound ...)
Affinity DataIC50: 0.550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent