BDBM568231 (2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol-5-yl)(5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone::US11420973, Example 109

SMILES CC(C)c1c([nH]c2ccc(cc12)C(=O)N1CC2CN(C)CC2C1)-c1cc(C)nc(C)c1

InChI Key InChIKey=KJRWCOZZYPOKFH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 568231   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568231((2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol...)
Affinity DataIC50: 18nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568231((2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol...)
Affinity DataIC50: 2.30nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568231((2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-1H-indol...)
Affinity DataIC50: 116nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent