BDBM568140 2-(3,4-dimethoxyphenyl)-N-[2-(dimethylamino)ethyl]-3-ethyl-1H-indole-5-carboxamide::US11420973, Example 17

SMILES CCc1c([nH]c2ccc(cc12)C(=O)NCCN(C)C)-c1ccc(OC)c(OC)c1

InChI Key InChIKey=WAABVBQVFJIJPA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 568140   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568140(2-(3,4-dimethoxyphenyl)-N-[2-(dimethylamino)ethyl]...)
Affinity DataIC50: 115nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568140(2-(3,4-dimethoxyphenyl)-N-[2-(dimethylamino)ethyl]...)
Affinity DataIC50: 7.90nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM568140(2-(3,4-dimethoxyphenyl)-N-[2-(dimethylamino)ethyl]...)
Affinity DataIC50: 2.51E+3nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent