BDBM566629 3-fluoro-5-(((1R,2S,2aS)-1,2,3,3,4,4-hexafluoro- 2a-hydroxy-2,2a,3,4-tetrahydro-1H- cyclopenta[cd]inden-7-yl)oxy)benzonitrile::US11420936, Compound 24a

SMILES O[C@]12[C@H](F)[C@H](F)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F

InChI Key InChIKey=XBKXKZWZHRTYSX-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 566629   

TargetVascular endothelial growth factor A(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM566629(3-fluoro-5-(((1R,2S,2aS)-1,2,3,3,4,4-hexafluoro- 2...)
Affinity DataEC50:  2nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetEndothelial PAS domain-containing protein 1(Human)
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM566629(3-fluoro-5-(((1R,2S,2aS)-1,2,3,3,4,4-hexafluoro- 2...)
Affinity DataEC50:  2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed