BDBM566622 3-fluoro-5-((1,3,3,4,4-pentafluoro-2a-hydroxy-1- methyl-2,2a,3,4-tetrahydro-1H- cyclopenta[cd]inden-7-yl)oxy)benzonitrile::US11420936, Compound 12

SMILES CC1(F)CC2(O)c3c(ccc(Oc4cc(F)cc(c4)C#N)c13)C(F)(F)C2(F)F

InChI Key InChIKey=VDGWINQLIBYLHJ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 566622   

TargetVascular endothelial growth factor A(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM566622(3-fluoro-5-((1,3,3,4,4-pentafluoro-2a-hydroxy-1- m...)
Affinity DataEC50:  100nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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