BDBM566619 3-fluoro-5-((3,3,4,4-tetrafluoro-2a-hydroxy- 2,2a,3,4-tetrahydrospiro[cyclopenta[cd]indene- 1,1'-cyclopropan]-7-yl)oxy)benzonitrile::US11420936, Compound 9

SMILES OC12CC3(CC3)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F

InChI Key InChIKey=FJODMIGZWNEGQW-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 566619   

TargetVascular endothelial growth factor A(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM566619(3-fluoro-5-((3,3,4,4-tetrafluoro-2a-hydroxy- 2,2a,...)
Affinity DataEC50:  170nMAssay Description:The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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