BDBM566472 3-(8-methoxy-1- methyl-2-oxo-7- phenyl-2,3-dihydro- 1H-benzo[e]- [1,4]diazepin-5-yl) benzamide::US11419874, ND-7001

SMILES COc1cc2N(C)C(=O)CN=C(c3cccc(c3)C(N)=O)c2cc1-c1ccccc1

InChI Key InChIKey=WYTGWTBNDXWMMB-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 566472   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM566472(US11419874, ND-7001 | 3-(8-methoxy-1- methyl-2-oxo...)
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]-cAMP from recombinant PDE2 (unknown origin) expressed in African green monkey COS-7 cells incubated for 30 mins in presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM566472(US11419874, ND-7001 | 3-(8-methoxy-1- methyl-2-oxo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Shaoxing University

Curated by ChEMBL
LigandPNGBDBM566472(US11419874, ND-7001 | 3-(8-methoxy-1- methyl-2-oxo...)
Affinity DataKi:  114nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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