BDBM566439 US11414431, Compound I-1009::US12221453, Compound I-1009

SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC)-c1cn(C(C)C)c2nnccc12

InChI Key InChIKey=ISNNFLRPNKQAKT-UHFFFAOYSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 566439   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM566439(US11414431, Compound I-1009 | US12221453, Compound...)
Affinity DataKd: <0.200nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM566439(US11414431, Compound I-1009 | US12221453, Compound...)
Affinity DataKd: <200nMAssay Description:Binding affinity to human wild-type partial length TYK2 JH2 (G556 to D888 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM566439(US11414431, Compound I-1009 | US12221453, Compound...)
Affinity DataIC50: 500nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human PBMC cells assessed as IL-12 induced p-STAT4 level incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM566439(US11414431, Compound I-1009 | US12221453, Compound...)
Affinity DataKd:  0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMVEscan® assay (D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent