BDBM565511 US11414431, Compound I-77::US12221453, Compound I-77

SMILES CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H](C1)OC

InChI Key InChIKey=AMMBLQMVCFYBFU-UHFFFAOYSA-N

Data  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 565511   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd:  5.5nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM565511(US11414431, Compound I-77 | US12221453, Compound I...)
Affinity DataKd:  5.5nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMVEscan® assay (D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent