BDBM565206 2-(4-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1,1-dioxotetrahydro-2H-thiopyran-4-yl)acetonitrile::US11414413, Example 3

SMILES O=S1(=O)CCC(CC#N)(CC1)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=BEXQNJWHZUKTBV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 565206   

TargetTyrosine-protein kinase JAK1(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565206(US11414413, Example 3 | 2-(4-(4-(7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 10.5nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565206(US11414413, Example 3 | 2-(4-(4-(7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 19nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565206(US11414413, Example 3 | 2-(4-(4-(7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 20nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565206(US11414413, Example 3 | 2-(4-(4-(7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 20nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565206(US11414413, Example 3 | 2-(4-(4-(7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 22nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565206(US11414413, Example 3 | 2-(4-(4-(7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 35nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent