BDBM565205 2-(4-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrazol-1-yl)-1,1-dioxotetrahydro-2H-thiopyran-4-yl)acetonitrile::US11414413, Example 2

SMILES O=S1(=O)CCC(CC#N)(CC1)n1cc(cn1)-c1c[nH]c2ncccc12

InChI Key InChIKey=IUIYXCQJESBBGY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565205   

TargetTyrosine-protein kinase JAK1(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565205(US11414413, Example 2 | 2-(4-(4-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 20nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565205(US11414413, Example 2 | 2-(4-(4-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 35nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Suzhou Longbiotech Pharmaceuticals

US Patent
LigandPNGBDBM565205(US11414413, Example 2 | 2-(4-(4-(1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 50nMAssay Description:The study of the effect of compounds on the activity of purified recombinant JAK was performed by studying the inhibitory activity of the compounds o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent