BDBM565178 US11414404, Ex. # 55::US11634409, Example 55

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2C)c1Cl

InChI Key InChIKey=JTHXHWJHYHTYEV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 565178   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565178(US11414404, Ex. # 55 | US11634409, Example 55)
Affinity DataIC50: 5.40nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565178(US11414404, Ex. # 55 | US11634409, Example 55)
Affinity DataIC50: 3.10nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565178(US11414404, Ex. # 55 | US11634409, Example 55)
Affinity DataIC50: 5.40nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565178(US11414404, Ex. # 55 | US11634409, Example 55)
Affinity DataIC50: 3.10nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details Go to US Patent