BDBM565175 N-(2-chloro-3-((3,5- dimethyl-4-oxo-3,4- dihydroquinazolin-6- yl)amino)-4- fluorophenyl)ethane- sulfonamide::US11414404, Ex. # 52::US11634409, Example 52

SMILES CCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2C)c1Cl

InChI Key InChIKey=FYOWFOVXGJCIFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565175   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565175(US11414404, Ex. # 52 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 226nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565175(US11414404, Ex. # 52 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 182nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565175(US11414404, Ex. # 52 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 169nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed