BDBM565157 (R)-N-(2-chloro-4-fluoro-3- ((5-methyl-4-oxo-3- (tetrahydrofuran-3-yl)-3,4- dihydroquinazolin-6- yl)amino)phenyl)propane- 1-sulfonamide trifluoroacetate::US11414404, Ex. # 34::US11634409, Example 34

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn([C@@H]4CCOC4)c(=O)c3c2C)c1Cl

InChI Key InChIKey=IPQYKBZFFJCTNS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 565157   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565157(US11414404, Ex. # 34 | (R)-N-(2-chloro-4-fluoro-3-...)
Affinity DataIC50: 8.90nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
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Date in BDB:
10/30/2022
Entry Details
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