BDBM565133 BDBM565146::US11414404, Ex. # 10::US11634409, Example 23

SMILES Cc1c(ccc2c1C(=O)N(C=N2)C)Nc3c(ccc(c3Cl)NS(=O)(=O)CCCF)F

InChI Key InChIKey=VVLVISDSGRHLMB-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 565133   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 4.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 3.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 4.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 3.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565133(US11414404, Ex. # 10 | BDBM565146 | US11634409, Ex...)
Affinity DataIC50: 2.70nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)