BDBM563531 8-(2-amino-6-((R)- 2,2,2-trifluoro-1-(3'- methoxy-[1,1'- biphenyl]-4- yl)ethoxy)pyrimidine-4- yl)-2-azaspiro[4.5]dec- 7-ene-3-carboxylic acid hydrochloride::US11407763, Example 87::US11407763, Example 89

SMILES COc1cccc(c1)-c1ccc(cc1)[C@@H](Oc1cc(nc(N)n1)C1=CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F

InChI Key InChIKey=IBHIGKVXOGCPAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 563531   

TargetTryptophan 5-hydroxylase 1(Human)
Gwangju Institute of Science and Technology

US Patent
LigandPNGBDBM563531(US11407763, Example 89 | 8-(2-amino-6-((R)- 2,2,2-...)
Affinity DataIC50: 741nMAssay Description:In order to confirm the inhibitory effect of the compound represented by formula 1 according to the present invention on the tryptophan hydroxylase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
Go to US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Gwangju Institute of Science and Technology

US Patent
LigandPNGBDBM563531(US11407763, Example 89 | 8-(2-amino-6-((R)- 2,2,2-...)
Affinity DataIC50: 409nMAssay Description:In order to confirm the inhibitory effect of the compound represented by formula 1 according to the present invention on the tryptophan hydroxylase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2022
Entry Details
Go to US Patent