BDBM56256 MLS000110334::N-(3-carbazol-9-yl-2-hydroxy-propyl)-N-(2-furfuryl)methanesulfonamide::N-(3-carbazol-9-yl-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide::N-(3-carbazol-9-yl-2-oxidanyl-propyl)-N-(furan-2-ylmethyl)methanesulfonamide::N-[3-(9-carbazolyl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide::SMR000106264::US10383880, Example 1::cid_2888648

SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1

InChI Key InChIKey=OQAFDLPAPSSOHY-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 56256   

TargetKallikrein-5(Human)
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM56256(N-(3-carbazol-9-yl-2-hydroxypropyl)-N-(furan-2-ylm...)
Affinity DataIC50: 5.00E+4nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Scott L. Diamond, University of Pennsy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2011
Entry Details
PCBioAssay
TargetPeriod circadian protein homolog 2(Human)
Reset Therapeutics

Curated by ChEMBL
LigandPNGBDBM56256(N-(3-carbazol-9-yl-2-hydroxypropyl)-N-(furan-2-ylm...)
Affinity DataEC50:  870nMAssay Description:Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythmsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
TargetCryptochrome-2(Human)TBA
LigandPNGBDBM56256(N-(3-carbazol-9-yl-2-hydroxypropyl)-N-(furan-2-ylm...)
Affinity DataEC50:  870nMAssay Description:Modulation activity at CRY2/PER2 in human U2OS cells harboring per2-dLuc assessed as activation of per2 activity measured every 100 mins for 5 days b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPeriod circadian protein homolog 2(Human)
Reset Therapeutics

Curated by ChEMBL
LigandPNGBDBM56256(N-(3-carbazol-9-yl-2-hydroxypropyl)-N-(furan-2-ylm...)
Affinity DataEC50:  340nMAssay Description:Per2 Assay for Evaluating the Potency of Test Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent