BDBM562400 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-17-(morpholin-4-yl)-11,12,14,15,16,17-hexahydro-2H,10H-pyrazolo[3',4':6,7][1,2,10]thiadiazacyclotridecino[8,9,10-hi]indole-8-carboxylic acid 13,13-dioxide trifluoroacetate salt (Enantiomer 2)::US11401278, Example 71

SMILES CCc1c-2c(nn1C)C(CCN(C)S(=O)(=O)CCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13)N1CCOCC1

InChI Key InChIKey=SOSFJVGXMDRHJQ-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562400   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43](Human)
The Broad Institute

US Patent

LigandBDBM562400(US11401278, Example 71 | (+)-4-chloro-3-ethyl-7-{3...)Copy SMILESCopy InChI

Affinity DataIC50: 0.800nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/23/2022
Entry Details
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