BDBM562359 (rac)-1-(3-((2,3-Dihydro-1H-inden-4-yl)oxy)propyl)-12-ethyl-13-fluoro-8,11-dimethyl-5,6,9,11-tetrahydro-4H,8H-pyrazolo[3′,4′:4,5][1]thia[2,8]diazacycloundecino[6,7,8-hi]indole-2-carboxylic acid 7,7-dioxide::US11401278, Example 32

SMILES CCc1c-2c(CN(C)S(=O)(=O)CCCn3c(C(O)=O)c(CCCOc4cccc5CCCc45)c4ccc(F)c-2c34)nn1C

InChI Key InChIKey=OIGDWZBUMLBHPF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562359   

LigandPNGBDBM562359(US11401278, Example 32 | (rac)-1-(3-((2,3-Dihydro-...)
Affinity DataIC50: 1.5nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562359(US11401278, Example 32 | (rac)-1-(3-((2,3-Dihydro-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562359(US11401278, Example 32 | (rac)-1-(3-((2,3-Dihydro-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent