BDBM562236 1-(1-cyclopropylcyclopropyl)-5-(cyclopropylmethyl)-3-oxo-7,8-dihydro-5H-pyrano-[1,2,4]triazolo[4,3-a]quinoxalin-4-one::US11401274, Example 6

SMILES O=c1n(CC2CC2)c2COCCc2n2c(nnc12)C1(CC1)C1CC1

InChI Key InChIKey=KPFXUWGXTIMYPE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 562236   

LigandPNGBDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 8.40nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 14.9nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
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Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 5.60nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 1.00E+5nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 3.92E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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LigandPNGBDBM562236(US11401274, Example 6 | 1-(1-cyclopropylcyclopropy...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent